The Hang Seng Index dropped 0.4 per cent to 25,837.80 as of 10.03am local time. The Hang Seng Tech Index dropped 0.5 per cent.
On the mainland, the CSI 300 Index climbed 0.1 per cent and the Shanghai Composite Index was little changed.
Trip.com Group tumbled 2.1 per cent to HK$544.50 and NetEase lost 1.8 per cent to HK$213.40. Alibaba Group Holding slid 0.8 per cent to HK$153.20 and Tencent Holdings slipped 0.8 per cent to HK$607.
Caution prevailed before the rate decision meetings by the Federal Reserve and the Bank of Japan in the coming week. While a rate cut in the US will boost risk appetite, a hike in Japan will increase the risk of unwinding the yen carry trade, causing turbulence across global financial markets.
China’s annual central economic work conference, expected to take place this month, is also in focus, with traders paying close attention to how Beijing will revive growth.
